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The COVID-19 pandemic has exacted a historic toll on Americans’ health and longevity. It has also shaped socioeconomic inequalities along the lines of gender, race, ethnicity, nativity, and class in America. The effects of COVID-19 are evident in the stratified experiences of Americans in work, unemployment, and unpaid labor; in stark inequalities in wealth and income; in the historic expansions and retrenchments in social welfare spending; and in the increase in violence and changes in the criminal justice system. While there has been an outpouring of research on the social and economic consequences of COVID-19, far less work draws together research across these varied, but interrelated, domains. In this introduction, we provide a broad narrative of how the COVID-19 pandemic unfolded in America and reshaped, in some instances fleetingly and in others more permanently, the landscape of socioeconomic inequality in America.