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In studies of discrimination, one popular strategy is to estimate disparities after adjusting for observed covariates, typically with a regression model. This approach, however, suffers from two key statistical challenges. First, omitted-variable bias can skew results if the model does not adjust for all relevant factors; second, and conversely, included-variable bias—a less well known phenomenon—can skew results if the set of covariates includes irrelevant factors. Here we introduce a new, three-step statistical method, which we call risk-adjusted regression, to address both concerns in settings where decision makers have clearly measurable objectives. In the first step, we use all available covariates to estimate the value, or inversely, the risk, of taking a certain action, such as approving a loan application or hiring a job candidate. Second, we measure disparities in decisions after adjusting for these risk estimates alone, mitigating the problem of included-variable bias. Finally, in the third step, we assess the sensitivity of results to potential mismeasurement of risk, addressing concerns about omitted-variable bias. To do so, we develop a novel, non-parametric sensitivity analysis that yields tight bounds on the true disparity in terms of the average gap between true and estimated risk—a single interpretable parameter that facilitates credible estimates. We demonstrate this approach on a detailed dataset of 2.2 million police stops of pedestrians in New York City, and show that traditional statistical tests of discrimination can substantially underestimate the magnitude of disparities.